Metgyl Tablet Mechanism of Action

Pharmacology: Pharmacodynamics: Mode or Mechanisms of Action: Antibacterial (systemic); antiprotozoal - Microbicidal; active against most obligate anaerobic bacteria and protozoa by undergoing intracellular chemical reduction via mechanisms unique to anaerobic metabolism. Reduced metronidazole, which is cytotoxic but short-lived, interacts with DNA to cause a loss of helical structure, strand breakage, and resultant inhibition of nucleic acid synthesis and cell death.
Metronidazole is very active against a wide range of pathogenic microorganisms especially species of bacteroides, fusobacteria, clostridia, eubacteria, anaerobic cocci and Gardnerella vaginalis.
It is also active against trichomonas, Entamoeba histolytica, Giardia lamblia and Balantidium coli.
Pharmacokinetics: Absorption: Well absorbed orally; bio-availability at least 80%.
Distribution: Distributed to saliva, bile, seminal fluid, breast milk, bone, liver and liver abscesses, lungs, and vaginal secretions; crosses the placenta and blood brain barrier, also.
Vol_D: ln adults: Approximately 0.55 l/kg.
Protein binding: Low (<20%).
Biotransformation: Hepatic.
Half-life: In adults: Normal liver function: 8 hours.
Time to peak serum concentration: 1 to 2 hours (oral).
Elimination: Renal: 60 to 80%; of this amount, approximately 20% excreted unchanged in urine.